There are different ways to reach Puyarruego:

From Zaragoza, Madrid, Valencia and Logroño:
Take the highway E-07 to Huesca, continue on road N-240 to Barbastro. Here you take the A-138 to Aínsa. In Aínsa, take the road to Bielsa and France. After about 10 km you arrive at Escalona and at the roundabout you take the road to Puyarruego and the Cañon de Añisclo.

From Pamplona and Bilbao: 
In Pamplona take the N-20 to Jaca. From there the N-330 to Sabiñanigo and then continue on the N-260 to Biescas, Boltaña and Aínsa.

From Barcelona and Lérida:
In Lérida take the road to Barbastro. Here continue on the A-138 to Aínsa, Bielsa andFrancia, to arrive in Escalona and Puyarruego.

From France:
From the direction of Bordeaux, join the highway A64-E80 (Bayonne-Toulouse) in Pau, take the direction Toulouse and leave at the Lannemezan exit (direction Spain, Zaragoza, tunel de Bielsa), follow to Saint Lary and continue in the direction of Spain and the tunnel. Once in Spain, continue to Escalona (about 40 km from the tunnel) where at the roundabout you take right to Puyarruego.
Coming from Toulouse: highway A64-E80 direction Bayonne and take the exit inLannemezan (see above).